The Cylinders took a 97-92 lead on Cade Cunningham's 3-pointer with 8:10 left in the final quarter, yet Brooklyn's 13-0 run gave it a 105-97 lead with 4:53 excess.
Detroit followed 112-110 with 57.9 seconds remaining however couldn't stop Brooklyn in the last moment.
Cunningham scored 37 of his game-high 41 focuses in the final part however keeping the Cylinders from infamy wasn't sufficient.
"You must be genuinely about where we are," Cylinders mentor Monty Williams said. "No one needs something like this joined to them. Main concern, it's my work.
No group with a .067 winning rate has a winnable game on its timetable, yet of the Cylinders' next seven games, five are out and about, and four are against groups with winning records